Acute cholesterol depletion impairs functional expression of tissue factor in fibroblasts: modulation of tissue factor activity by membrane cholesterol
نویسندگان
چکیده
منابع مشابه
Membrane-mediated synthesis of tissue factor (thromboplastin) in cultured fibroblasts.
A potent procoagulant synthesized by mycin. Tissue factor production is related cultured human skin fibroblasts has been to the shape change that occurs as the identified as tissue factor (factor Iii, thromcells spread on the floor of the culture boplastin), since it binds factor VII and is vessel, but tissue factor is not synonymous blocked by a specific antitissue factor with the configuratio...
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Intact bovine fibroblasts, pericytes, and kidney cells manifested significantly less tissue factor procoagulant activity than their disrupted counterparts. Addition of calcium ionophore A23187 rapidly and reversibly enhanced the cell-surface expression of tissue factor in intact cells up to the level achieved by disruption. Inhibitors of calmodulin blocked the ionophore-dependent enhancement of...
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ژورنال
عنوان ژورنال: Blood
سال: 2005
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2004-03-0990